Copper Supplement (Oral Route, Parenteral Route)

Description and Brand Names

Drug information provided by: Merative, Micromedex®

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Descriptions

Copper supplements are used to prevent or treat copper deficiency.

The body needs copper for normal growth and health. For patients who are unable to get enough copper in their regular diet or who have a need for more copper, copper supplements may be necessary. They are generally taken by mouth but some patients may have to receive them by injection. Copper is needed to help your body use iron. It is also important for nerve function, bone growth, and to help your body use sugar.

Lack of copper may lead to anemia and osteoporosis (weak bones).

Some conditions may increase your need for copper. These include:

• Burns
• Diarrhea
• Intestine disease
• Kidney disease
• Pancreas disease
• Stomach removal
• Stress, continuing

Increased need for copper should be determined by your health care professional.

Claims that copper supplements are effective in the treatment of arthritis or skin conditions have not been proven. Use of copper supplements to cause vomiting has caused death and should be avoided.

Injectable copper is given by or under the supervision of a health care professional. Another form of copper is available without a prescription.

Importance of Diet

For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.

Copper is found in various foods, including organ meats (especially liver), seafood, beans, nuts, and whole-grains. Additional copper can come from drinking water from copper pipes, using copper cookware, and eating farm products sprayed with copper-containing chemicals. Copper may be decreased in foods that have high acid content and are stored in tin cans for a long time.

For U.S.—

• Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person's age, sex, and physical condition (e.g., pregnancy).
• Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs).

For Canada—

• Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.

There is no RDA or RNI for copper. However, normal daily recommended intakes are generally defined as follows:

• Infants and children—
  • Birth to 3 years of age: 0.4 to 1 milligram (mg) per day.
  • 4 to 6 years of age: 1 to 1.5 mg per day.
  • 7 to 10 years of age: 1 to 2 mg per day.
• Adolescent and adult males—1.5 to 2.5 mg per day.
• Adolescent and adult females—1.5 to 3 mg per day.

This product is available in the following dosage forms:

• Tablet

Abdullah, A. Z., Strafford, S. M., Brookes, S. J., and Duggal, M. S. "The effect of copper on demineralization of dental enamel." J Dent Res 2006;85(11):1011-1015. View abstract.

Araya, M., McGoldrick, M. C., Klevay, L. M., Strain, J. J., Robson, P., Nielsen, F., Olivares, M., Pizarro, F., Johnson, L. A., and Poirier, K. A. "Determination of an acute no-observed-adverse-effect level (NOAEL) for copper in water." Regul.Toxicol.Pharmacol. 2001;34(2):137-145. View abstract.

Araya, M., Olivares, M., Pizarro, F., Llanos, A., Figueroa, G., and Uauy, R. "Community-based randomized double-blind study of gastrointestinal effects and copper exposure in drinking water." Environ.Health Perspect. 2004;112(10):1068-1073. View abstract.

Ashkenazi, A., Levin, S., Djaldetti, M., Fishel, E., and Benvenisti, D. "The syndrome of neonatal copper deficiency." Pediatrics 1973;52(4):525-533. View abstract.

August, D., Janghorbani, M., and Young, V. R. "Determination of zinc and copper absorption at three dietary Zn-Cu ratios by using stable isotope methods in young adult and elderly subjects." Am J Clin Nutr 1989;50(6):1457-1463. View abstract.

Baker, A., Harvey, L., Majask-Newman, G., Fairweather-Tait, S., Flynn, A., and Cashman, K. "Effect of dietary copper intakes on biochemical markers of bone metabolism in healthy adult males." Eur.J.Clin.Nutr. 1999;53(5):408-412. View abstract.

Baker, A., Turley, E., Bonham, M. P., O'Connor, J. M., Strain, J. J., Flynn, A., and Cashman, K. D. "No effect of copper supplementation on biochemical markers of bone metabolism in healthy adults." Br.J.Nutr. 1999;82(4):283-290. View abstract.

BAKWIN, R. M. "Ceruloplasmin activity and copper levels in the serum of children with schizophrenia." J Am Med Womens Assoc 1961;16:522-523. View abstract.

BAKWIN, R. M., MOSBACH, E. H., and BAKWIN, H. "Concentration of copper in serum of children with schizophrenia." Pediatrics 1961;27:642-644. View abstract.

Bonham, M., O'Connor, J. M., McAnena, L. B., Walsh, P. M., Downes, C. S., Hannigan, B. M., and Strain, J. J. "Zinc supplementation has no effect on lipoprotein metabolism, hemostasis, and putative indices of copper status in healthy men." Biol.Trace Elem.Res. 2003;93(1-3):75-86. View abstract.

Bowman, M. B. and Lewis, M. S. "The copper hypothesis of schizophrenia: a review." Neurosci.Biobehav.Rev 1982;6(3):321-328. View abstract.

Brown, N. A., Bron, A. J., Harding, J. J., and Dewar, H. M. "Nutrition supplements and the eye." Eye 1998;12 ( Pt 1):127-133. View abstract.

Bugel, S., Harper, A., Rock, E., O'Connor, J. M., Bonham, M. P., and Strain, J. J. "Effect of copper supplementation on indices of copper status and certain CVD risk markers in young healthy women." Br.J Nutr 2005;94(2):231-236. View abstract.

Burdeinyi, A. F. "[Levels of copper and zinc in the blood of patients with various types of schizophrenia]." Zh.Nevropatol.Psikhiatr.Im S.S.Korsakova 1967;67(7):1041-1043. View abstract.

Bureau, I., Lewis, C. G., and Fields, M. "Effect of hepatic iron on hypercholesterolemia and hypertriacylglycerolemia in copper-deficient fructose-fed rats." Nutrition 1998;14(4):366-371. View abstract.

Cashman, K. D., Baker, A., Ginty, F., Flynn, A., Strain, J. J., Bonham, M. P., O'Connor, J. M., Bugel, S., and Sandstrom, B. "No effect of copper supplementation on biochemical markers of bone metabolism in healthy young adult females despite apparently improved copper status." Eur.J.Clin.Nutr. 2001;55(7):525-531. View abstract.

Castillo-Duran, C., Fisberg, M., Valenzuela, A., Egana, J. I., and Uauy, R. "Controlled trial of copper supplementation during the recovery from marasmus." Am.J.Clin.Nutr. 1983;37(6):898-903. View abstract.

Chitre, V. S. and Punekar, B. D. "Changes in serum copper and PPD-oxidase in different diseases. II. Comparative studies in Wilson's disease schizophrenia and Parkinsonism." Indian J Med Res 1970;58(5):563-573. View abstract.

Christodoulou, J., Danks, D. M., Sarkar, B., Baerlocher, K. E., Casey, R., Horn, N., Tumer, Z., and Clarke, J. T. "Early treatment of Menkes disease with parenteral copper-histidine: long-term follow-up of four treated patients." Am J Med Genet. 3-5-1998;76(2):154-164. View abstract.

Chugh, T. D., Dhingra, R. K., Gulati, R. C., and Bathla, J. C. "Copper metabolism in schizophrenia." Indian J Med Res 1973;61(8):1147-1152. View abstract.

Czeizel, A. E. and Dudas, I. "Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation." N Engl.J Med 12-24-1992;327(26):1832-1835. View abstract.

da Silveira, S. V., Canato, C., de Jorge, F. B., and Delascio, D. "[Copper, iron, magnesium and sulfur in the serum of pregnant women with sideroblastic anemia before, during, and after parenteral iron infusion therapy]." Matern.Infanc.(Sao Paulo) 1967;26(3):269-273. View abstract.

DOGAN, S., KELER, M., and PERSIC, N. "[Copper in blood in schizophrenia; a problem of pathophysiology of schizophrenia.]." Acta Med Iugosl. 1955;9(1):60-70. View abstract.

Fiske, D. N., McCoy, H. E., III, and Kitchens, C. S. "Zinc-induced sideroblastic anemia: report of a case, review of the literature, and description of the hematologic syndrome." Am J Hematol. 1994;46(2):147-150. View abstract.

Freycon, F. and Pouyau, G. "[Rare nutritional deficiency anemia: deficiency of copper and vitamin E]." Sem.Hop. 2-17-1983;59(7):488-493. View abstract.

George, D. H. and Casey, R. E. "Menkes disease after copper histidine replacement therapy: case report." Pediatr Dev.Pathol. 2001;4(3):281-288. View abstract.

Gillin, J. C., Carpenter, W. T., Hambidge, K. M., Wyatt, R. J., and Henkin, R. I. "Zinc and copper in patients with schizophrenia." Encephale 1982;8(3):435-444. View abstract.

Gorter, R. W., Butorac, M., and Cobian, E. P. "Examination of the cutaneous absorption of copper after the use of copper-containing ointments." Am J Ther 2004;11(6):453-458. View abstract.

Gregg, X. T., Reddy, V., and Prchal, J. T. "Copper deficiency masquerading as myelodysplastic syndrome." Blood 8-15-2002;100(4):1493-1495. View abstract.

Harvey, L. J., Majsak-Newman, G., Dainty, J. R., Lewis, D. J., Langford, N. J., Crews, H. M., and Fairweather-Tait, S. J. "Adaptive responses in men fed low- and high-copper diets." Br J Nutr 2003;90(1):161-168. View abstract.

Henry, N. L., Dunn, R., Merjaver, S., Pan, Q., Pienta, K. J., Brewer, G., and Smith, D. C. "Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer." Oncology 2006;71(3-4):168-175. View abstract.

Herran, A., Garcia-Unzueta, M. T., Fernandez-Gonzalez, M. D., Vazquez-Barquero, J. L., Alvarez, C., and Amado, J. A. "Higher levels of serum copper in schizophrenic patients treated with depot neuroleptics." Psychiatry Res 4-24-2000;94(1):51-58. View abstract.

Humphries, W. R., Phillippo, M., Young, B. W., and Bremner, I. "The influence of dietary iron and molybdenum on copper metabolism in calves." Br.J.Nutr. 1983;49(1):77-86. View abstract.

Institute of Medicine ed. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2000). National Academy Press;2000.

Irving, J. A., Mattman, A., Lockitch, G., Farrell, K., and Wadsworth, L. D. "Element of caution: a case of reversible cytopenias associated with excessive zinc supplementation." CMAJ. 7-22-2003;169(2):129-131. View abstract.

Jendryczko, A., Drozdz, M., and Magner, K. "Antilupus activity of copper (II)." Exp Pathol. 1985;28(3):187-189. View abstract.

Kappel, L. C., Ingraham, R. H., Morgan, E. B., and Babcock, D. K. "Plasma copper concentration and packed cell volume and their relationships to fertility and milk production in Holstein cows." Am.J.Vet.Res. 1984;45(2):346-350. View abstract.

Kelley, D. S., Daudu, P. A., Taylor, P. C., Mackey, B. E., and Turnlund, J. R. "Effects of low-copper diets on human immune response." Am.J.Clin.Nutr. 1995;62(2):412-416. View abstract.

Kessler, H., Bayer, T. A., Bach, D., Schneider-Axmann, T., Supprian, T., Herrmann, W., Haber, M., Multhaup, G., Falkai, P., and Pajonk, F. G. "Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial." J Neural Transm. 2008;115(8):1181-1187. View abstract.

Kimura, A., Yoshino, H., and Yuasa