Tizanidine (Oral Route) Side Effects

Description and Brand Names

Drug information provided by: Merative, Micromedex®

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US Brand Name

1. Comfort Pac wTizanidine
2. Zanaflex
3. Zanaflex Capsule

Descriptions

Tizanidine is a muscle relaxant that helps alleviate spasms, cramping, and muscle tightness caused by medical issues such as multiple sclerosis or spinal injuries. Although it does not cure these conditions, it can enhance the efficacy of other treatments like physical therapy.

This medication functions through its action on the central nervous system (CNS), which also accounts for some of its side effects.

This medicine is only available with a doctor’s prescription.

This product comes in the following forms:

• Tablet
• Capsule

Before Using

When deciding to use medication, it is crucial to weigh the benefits against potential risks. This is a decision you should make with your doctor. Consider the following:

Allergies

Inform your doctor if you have had any previous unusual or allergic reactions to this or any other medicines. Also, disclose any other allergies, including those to foods, dyes, preservatives, or animals.

Pediatric

No appropriate studies have yet been conducted to determine the safety and efficacy of tizanidine in children.

Geriatric

Studies conducted so far have not shown geriatric-specific issues that would limit the utility of tizanidine in elderly patients. However, elderly patients are more prone to kidney issues, which require caution when administering this medicine.

Breastfeeding

There are inadequate studies in breastfeeding women to determine infant risk. Weigh the potential benefits against potential risks before use.

Drug Interactions

Certain medicines should not be used together, while others may be used together under specific circumstances. Here’s what you should know:

Using this medicine with any of the following is not recommended:

• Ciprofloxacin
• Fluvoxamine
• Potassium Citrate
• Viloxazine

The following medicines usually should not be used together but might be necessary in some cases:

• Adagrasib
• Alfentanil
• Alprazolam
• and more...

Other Interactions

Using this medicine with the following may cause interactions:

• Tobacco

Other Medical Problems

Inform your doctor if you have other medical issues, particularly:

• Kidney disease
• Liver disease (use with caution)

Proper Use

Follow your doctor’s instructions to avoid increased risks of side effects.

Dosing

Doses will vary; follow your doctor’s orders for dosage and timing:

• For oral dosage forms (capsules or tablets):
  • Adults: Start with 2 mg every 6 to 8 hours; do not exceed 36 mg within 24 hours.
  • Children: Consult your doctor.

Missed Dose

If you miss a dose, take it as soon as you remember unless it is almost time for your next dose.

Storage

Store at room temperature in a closed container away from light and moisture.

Precautions

Your doctor should monitor your progress, especially in the initial weeks of treatment.

Avoid using ciprofloxacin or fluvoxamine with tizanidine to prevent serious side effects.

If you experience symptoms like upper stomach pain, dark urine, loss of appetite, and jaundice, seek medical help immediately.

Tizanidine can enhance the effects of CNS depressants and alcohol. Consult your healthcare provider before using them together.

Be cautious when performing tasks that require alertness as this medicine may cause dizziness, drowsiness, or vision problems.

Recognize early symptoms of severe allergic reactions or hallucinations and contact your healthcare provider if they occur.

Do not abruptly stop this medication without consulting your doctor. Gradual reduction is recommended to avoid withdrawal symptoms.

Tizanidine may cause dry mouth. Use sugarless products or saliva substitutes for relief and consult a dentist if dryness persists for more than two weeks.

Side Effects

Possible side effects range from common to severe and should be monitored. Consult your doctor if you experience:

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More common side effects:

1. Chest pain or discomfort
2. Fever or chills
3. Nausea or vomiting
4. Nervousness
5. Pain or burning while urinating
6. Unusual tiredness

Less common side effects:

1. Blurred vision
2. Flu-like symptoms
3. Irregular heartbeat
4. Itching skin
5. Kidney stones
6. Right upper stomach tenderness
7. Hallucinations
8. Shortness of breath
9. Weight gain

Incidence not known:

1. Continuing vomiting
2. General tiredness or weakness
3. Headache
4. Light-colored stools

Symptoms of overdose:

1. Blurred vision
2. Change in consciousness
3. Chest pain or discomfort
4. Confusion
5. Decreased awareness or responsiveness
6. Difficult breathing
7. Dizziness when getting up
8. Irregular, fast, or slow breathing
9. Loss of consciousness
10. Pale or blue lips, fingernails, or skin
11. Severe sleepiness
12. Unusual tiredness or weakness
13. Sweating

Less severe side effects may occur as your body adjusts to the medication. If they persist, consult your healthcare professional.

More common:

1. Dizziness or lightheadedness
2. Drowsiness
3. Dry mouth
4. Fatigue
5. Weakness

Less common:

1. Constipation
2. Nervousness
3. Sore throat

For any other side effects, consult your healthcare professional. Call your doctor for medical advice about side effects and report them to the FDA at 1-800-FDA.

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